| http://purl.uniprot.org/citations/17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17639289 | http://www.w3.org/2000/01/rdf-schema#comment | "Clostridium difficile toxin A causes acute colitis associated with intense infiltration of neutrophils. Although C. difficile toxin A is known to induce nuclear factor-kappaB-mediated chemokine expression in intestinal epithelial cells, little is known about its effect on the regulation of activator protein-1 (AP-1) by mitogen-activated protein kinase (MAPK). In the present study, we investigated whether the MAPK and AP-1 signaling pathway is involved in interleukin (IL)-8 expression and enteric inflammation in response to stimulation with toxin A. Toxin A activated MAPK and AP-1 composed of c-Jun/c-Fos heterodimers in primary intestinal epithelial cells and HT-29 cell lines. Transfection with mutant genes for Ras, c-Jun, p38, or c-Jun N-terminal kinase (JNK) significantly inhibited C. difficile toxin A-induced activation of AP-1 and expression of IL-8 in HT-29 cell lines. Furthermore, the p38 inhibitor SB203580 attenuated toxin A-induced inflammation in vivo in the mouse ileum, evidenced by a significant decrease in neutrophil infiltration, villous destruction, and mucosal congestion. Our results suggest that the Ras/MAPK cascade acts as the upstream signaling for AP-1 activation and IL-8 expression in toxin A-stimulated intestinal epithelial cells and may be involved in the development of enteritis after infection with toxin A-producing C. difficile."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00109-007-0237-7"xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Kim J.M."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Youn J."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Han J.S."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Park H.R."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/author | "Oh Y.K."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/name | "J Mol Med (Berl)"xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/pages | "1393-1404"xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/title | "Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A."xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/17639289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17639289 |
| http://purl.uniprot.org/citations/17639289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17639289 |
| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_P01100-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_P05412-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_Q6FG41-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_Q6FHK0-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |
| http://purl.uniprot.org/uniprot/#_Q76MY9-mappedCitation-17639289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17639289 |