| http://purl.uniprot.org/citations/17640527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17640527 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal L-type calcium channels contribute to dendritic excitability and activity-dependent changes in gene expression that influence synaptic strength. Phosphorylation-mediated enhancement of L-type channels containing the CaV1.2 pore-forming subunit is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dependent protein kinase (PKA) to the channel. Although PKA increases L-type channel activity in dendrites and dendritic spines, the mechanism of enhancement in neurons remains poorly understood. Here, we show that CaV1.2 interacts directly with AKAP79/150, which binds both PKA and the Ca2+/calmodulin-activated phosphatase calcineurin (CaN). Cotargeting of PKA and CaN by AKAP79/150 confers bidirectional regulation of L-type current amplitude in transfected HEK293 cells and hippocampal neurons. However, anchored CaN dominantly suppresses PKA enhancement of the channel. Additionally, activation of the transcription factor NFATc4 via local Ca2+ influx through L-type channels requires AKAP79/150, suggesting that this signaling complex promotes neuronal L channel signaling to the nucleus through NFATc4."xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.06.032"xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/author | "Dell'Acqua M.L."xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/author | "Sather W.A."xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/author | "Oliveria S.F."xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/pages | "261-275"xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/title | "AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling."xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://purl.uniprot.org/core/volume | "55"xsd:string |
| http://purl.uniprot.org/citations/17640527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17640527 |
| http://purl.uniprot.org/citations/17640527 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17640527 |
| http://purl.uniprot.org/uniprot/P24588#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
| http://purl.uniprot.org/uniprot/D3YVF0#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
| http://purl.uniprot.org/uniprot/P24587#attribution-3C30076D772C49B4C9B308339C8507F9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
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| http://purl.uniprot.org/uniprot/P48454#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
| http://purl.uniprot.org/uniprot/Q08209#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
| http://purl.uniprot.org/uniprot/P48453#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |
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| http://purl.uniprot.org/uniprot/P63328#attribution-2D58778E5A9EAA1043D6952717E62E44 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17640527 |