| http://purl.uniprot.org/citations/17641031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17641031 | http://www.w3.org/2000/01/rdf-schema#comment | "Respiratory syncytial virus (RSV) is a ubiquitous virus that preferentially infects airway epithelial cells, causing asthma exacerbations and severe disease in immunocompromised hosts. Acute RSV infection induces inflammation in the lung. Thymus- and activation-regulated chemokine (TARC) recruits Th2 cells to sites of inflammation. We found that acute RSV infection of BALB/c mice increased TARC production in the lung. Immunization of BALB/c mice with individual RSV proteins can lead to the development of Th1- or Th2-biased T cell responses in the lung after RSV infection. We primed animals with a recombinant vaccinia virus expressing either the RSV fusion (F) protein or the RSV attachment (G) protein, inducing Th1- and Th2-biased pulmonary memory T cell responses, respectively. After RSV infection, TARC production significantly increased in the vaccinia virus G-primed animals only. These data suggest a positive feedback loop for TARC production between RSV infection and Th2 cytokines. RSV-infected lung epithelial cells cultured with IL-4 or IL-13 demonstrated a marked increase in the production of TARC. The synergistic effect of RSV and IL-4/IL-13 on TARC production reflected differential induction of NF kappa B and STAT6 by the two stimuli (both are in the TARC promoter). These findings demonstrate that RSV induces a chemokine TARC that has the potential to recruit Th2 cells to the lung."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.3.1648"xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Hunninghake G.W."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Monick M.M."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Varga S.M."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Barrett C.W."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Yarovinsky T.O."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Hassan I."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Powers L.S."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Castilow E.M."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Groskreutz D."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/author | "Tifrea D."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/pages | "1648-1658"xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/title | "Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17."xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17641031 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17641031 |
| http://purl.uniprot.org/citations/17641031 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17641031 |
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| http://purl.uniprot.org/uniprot/Q9WUZ6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17641031 |