| http://purl.uniprot.org/citations/17652078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17652078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17652078 | http://www.w3.org/2000/01/rdf-schema#comment | "Transporters of nucleotide sugars regulate the availability of these substrates required for glycosylation reactions in the lumen of the Golgi apparatus and play an important role in the development of multicellular organisms. Caenorhabditis elegans has seven different sugars in its glycoconjugates, although 18 putative nucleotide sugar transporters are encoded in the genome. Among these, SQV-7, SRF-3, and CO3H5.2 exhibit partially overlapping substrate specificity and expression patterns. We now report evidence of functional redundancy between transporters CO3H5.2 and SRF-3. Reducing the activity of the CO3H5.2 gene product by RNA interference (RNAi) in SRF-3 mutants results in oocyte accumulation and abnormal gonad morphology, whereas comparable RNAi treatment of wild type or RNAi hypersensitive C. elegans strains does not cause detectable defects. We hypothesize this genetic enhancement to be a mechanism to ensure adequate glycoconjugate biosynthesis required for normal tissue development in multicellular organisms. Furthermore, we show that transporters SRF-3 and CO3H5.2, which are closely related in the phylogenetic tree, share a simultaneous and independent substrate transport mechanism that is different from the competitive one previously demonstrated for transporter SQV-7, which shares a lower amino acid sequence identity with CO3H5.2 and SRF-3. Therefore, different mechanisms for transporting multiple nucleotide sugars may have evolved parallel to transporter amino acid divergence."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704485200"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704485200"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Hirschberg C.B."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Hirschberg C.B."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Berninsone P.M."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Berninsone P.M."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Caffaro C.E."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/author | "Caffaro C.E."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/pages | "27970-27975"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/pages | "27970-27975"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/title | "Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/title | "Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism."xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17652078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17652078 |
| http://purl.uniprot.org/citations/17652078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17652078 |
| http://purl.uniprot.org/citations/17652078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17652078 |
| http://purl.uniprot.org/citations/17652078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17652078 |