| http://purl.uniprot.org/citations/17652091 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17652091 | http://www.w3.org/2000/01/rdf-schema#comment | "UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase) mediates the first step in the synthesis of the mannose 6-phosphate recognition marker on acid hydrolases. The transferase exists as an alpha(2)beta(2)gamma(2) hexameric complex with the alpha- and beta-subunits derived from a single precursor molecule. The catalytic function of the transferase is attributed to the alpha- and beta-subunits, whereas the gamma-subunit is believed to be involved in the recognition of a conformation-dependent protein determinant common to acid hydrolases. Using knock-out mice with mutations in either the alpha/beta gene or the gamma gene, we show that disruption of the alpha/beta gene completely abolishes phosphorylation of high mannose oligosaccharides on acid hydrolases whereas knock-out of the gamma gene results in only a partial loss of phosphorylation. These findings demonstrate that the alpha/beta-subunits, in addition to their catalytic function, have some ability to recognize acid hydrolases as specific substrates. This process is enhanced by the gamma-subunit."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m704067200"xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/author | "Kornfeld S."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/author | "Vogel P."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/author | "Lee W.S."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/author | "Gelfman C.M."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/author | "Payne B.J."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/pages | "27198-27203"xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/title | "Murine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases."xsd:string |
| http://purl.uniprot.org/citations/17652091 | http://purl.uniprot.org/core/volume | "282"xsd:string |
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