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http://purl.uniprot.org/citations/17652892http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Patients with hypertrophic cardiomyopathy (HCM) frequently complain of angina-like symptoms in the absence of organic coronary stenoses. Coronary spasm might cause myocardial ischemia in HCM patients. Delta-sarcoglycan plays a crucial role in the pathogenesis of HCM and coronary spasm in a mouse model.

Methods and results

This is a retrospective, single-center study with a small sample size. Seventy patients with HCM underwent coronary angiography and received acetylcholine provocation test. Coronary risk factors and 5'-untranslated region (UTR) G to C polymorphism on delta-sarcoglycan gene (n=64) were evaluated in the HCM patients. In 31 (44.3%) of 70 HCM patients, coronary spasm was induced by the provocation. None of the coronary risk factors was significantly different between the coronary spasm group and the non-coronary spasm group. The 5'-UTR gene polymorphism was associated with the occurrence of coronary spasm with an additive effect on the coexistence (p=0.025). Multiple logistic regression analysis showed that the C allele of 5'-UTR polymorphism was a significant risk factor for coronary spasm in patients with HCM (odds ratio, 3.1; 95% confidence interval, 1.0 to 9.5; p=0.045) that was independent of traditional coronary risk factors.

Conclusions

The 5'-UTR polymorphism on delta-sarcoglycan gene was associated with coronary spasm in Japanese patients with HCM."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.org/dc/terms/identifier"doi:10.1253/circj.71.1263"xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/author"Honda T."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/author"Ogawa H."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/author"Sakamoto T."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/author"Sugiyama S."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/author"Kaikita K."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/name"Circ J"xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/pages"1263-1267"xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/title"Impact of delta-sarcoglycan gene polymorphism on the occurrence of coronary spastic angina in Japanese patients with hypertrophic cardiomyopathy."xsd:string
http://purl.uniprot.org/citations/17652892http://purl.uniprot.org/core/volume"71"xsd:string
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