| http://purl.uniprot.org/citations/17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17653284 | http://www.w3.org/2000/01/rdf-schema#comment | "A recent high-density linkage screen confirmed that the HLA complex contains the strongest genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium analysis using 650 single nucleotide polymorphisms (SNP) markers of the HLA complex mapped the entire genetic effect to the HLA-DR-DQ subregion, reflected by the well-established risk haplotype HLA-DRB1*15,DQB1*06. Contrary to this, in a cohort of 1,084 MS patients and 1,347 controls, we show that the HLA-A gene confers an HLA-DRB1 independent influence on the risk of MS (P = 8.4x10(-10)). This supports the opposing view, that genes in the HLA class I region indeed exert an additional influence on the risk of MS, and confirms that the class I allele HLA-A*02 is negatively associated with the risk of MS (OR = 0.63, P = 7x10(-12)) not explained by linkage disequilibrium with class II. The combination of HLA-A and HLA-DRB1 alleles, as represented by HLA-A*02 and HLA-DRB1*15, was found to influence the risk of MS 23-fold. These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0000664"xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Hillert J."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Palmgren J."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Duvefelt K."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Jonasdottir G."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Akesson E."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Brynedal B."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/author | "Roos I.M."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/pages | "e664"xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/title | "HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/17653284 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17653284 |
| http://purl.uniprot.org/citations/17653284 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-17653284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17653284 |