| http://purl.uniprot.org/citations/17658278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17658278 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch signaling plays multiple roles to direct diverse decisions regarding cell fate during T cell development. During helper T (Th) cell differentiation, Notch is involved in generating optimal Th2 cell responses. Here, we present data investigating how Notch mediates Th2 cell differentiation. Notch showed a CD4(+) T cell intrinsic role in promoting IL-4 expression that required GATA-3. In the absence of Notch signals, Gata3 expression was markedly diminished. Introduction of an activated allele of Notch1 into CD4(+) T cells led to the specific and direct upregulation of a developmentally regulated Gata3 transcript that included the exon 1a sequences. Furthermore, Notch acted in parallel with GATA-3 to synergistically activate IL-4 expression. Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.04.018"xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Fang T.C."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Blacklow S.C."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Pear W.S."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Del Bianco C."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Yashiro-Ohtani Y."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/author | "Knoblock D.M."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/pages | "100-110"xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/title | "Notch directly regulates Gata3 expression during T helper 2 cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/17658278 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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