| http://purl.uniprot.org/citations/17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17660221 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesThe objective of this study was to investigate the association between genes (HLA-DRB1 and PTPN22) and tobacco smoking, separately as well as combined, and serological markers of rheumatoid arthritis (RA) in a French population with RA.Methods274 patients with RA with half of them belonging to RA multicase families, were genotyped for HLA-DRB1 allele and for PTPN22-1858 polymorphism. IgM rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies were determined by ELISA method. The search for association relied on chi(2) test and odds ratio with 95% confidence interval calculation. The interaction study relied on the departure-from-additivity-based method.ResultsThe presence of at least one shared epitope (SE) allele was associated with anti-CCP antibodies presence (82.5% vs. 68.4%, p = 0.02), particularly with HLA-DRB1*0401 allele (28.0% vs. 16.4%, p = 0.01). Tobacco exposure was associated with anti-CCP antibodies, but only in presence of SE. A tendency toward an interaction was found between tobacco, the presence of at least one HLA-DRB1*0401 allele and anti-CCP antibodies (attributable proportion due to interaction = +0.24 (-0.21+0.76)). The cumulative dose of cigarette smoking was correlated with anti-CCP antibody titres (r = 0.19, p = 0.04). The presence of both SE and 1858T alleles was associated with a higher, but not significantly different, risk for anti-CCP antibodies presence than for each separately. No association was found between PTPN22-1858T allele and tobacco smoking for autoantibody positivity.ConclusionsOur findings suggest an association between SE alleles and tobacco smoking for anti-CCP positivity and a tendency toward an interaction between the HLA-DRB1*0401 allele and smoking for anti-CCP positivity in this sample of RA."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.org/dc/terms/identifier | "doi:10.1136/ard.2007.075622"xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Dieude P."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Prum B."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Michou L."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Bardin T."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Cornelis F."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Lasbleiz S."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Pierlot C."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Teixeira V.H."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/author | "Petit-Teixeira E."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/name | "Ann Rheum Dis"xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/pages | "466-470"xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/title | "Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17660221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17660221 |
| http://purl.uniprot.org/citations/17660221 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-17660221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17660221 |