http://purl.uniprot.org/citations/17661909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/17661909 | http://www.w3.org/2000/01/rdf-schema#comment | "The distribution of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 haplotypes was analyzed separately in two distinct French ethnic groups with type I diabetes (T1D), i.e. French North African migrants (n= 64, mean age at diagnosis = 8.25 years) and ancient French natives (n= 60, mean age at diagnosis = 7.42 years). HLA associations were determined by calculating odds ratios (ORs) between patients and two ethnic-matched control populations. Results show highly similar ORs for the conservative DRB1*0301-DQA1*0501-DQB1*0201 haplotype of susceptibility (OR: 3.22 and 3.93 in migrants and natives, respectively) and the DRB1*1501-DQA1*0102-DQB1*0602 haplotype of resistance (OR: 0.05 and 0.03, respectively). In contrast, among the more variable DRB1*04-DQB1*0302 haplotypes of susceptibility, the DRB1*0402 (OR: 3.10 and 32.84) and 0405 (OR: 5.90 and 16.25, respectively) were associated with T1D in migrants and natives, whereas an increase of DRB1*0401, a rare allele in migrants, was significant in natives only. Also, among the DRB1*11-DQA1*0505-DQB1*0301 haplotypes of resistance, the OR observed for DRB1*1104-DQA1*0505-DQB1*0301, common in migrants, was lower (OR: 0.08) than for DRB1*1101-DQA1*0505-DQB1*0301 (OR: 0.32), common in natives. How DRB1*11 subtypes might affect differently the risk conferred by DQA1*0505-DQB1*0301 will be discussed."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0039.2007.00878.x"xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Tubiana-Rufi N."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Guerin V."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Leniaud L."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Pedron B."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Sterkers G."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/author | "Guilmin-Crepon S."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/pages | "214-218"xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/title | "HLA-associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives."xsd:string |
http://purl.uniprot.org/citations/17661909 | http://purl.uniprot.org/core/volume | "70"xsd:string |
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http://purl.uniprot.org/citations/17661909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17661909 |
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