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http://purl.uniprot.org/citations/17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17662350http://www.w3.org/2000/01/rdf-schema#comment"

Background

Although cavernomas are the most common brain vascular malformations, the etiology and risk factor(s) are still not entirely known. Recent publications focusing on the molecular basis suggest that genetic factors may play a role in the development of the brain vascular malformations. We aimed to show HLA typing in brain cavernoma in a group of Turkish patients.

Methods

This study compared HLA types of 30 patients who had brain cavernoma with 30 healthy controls.

Results

The analysis of HLA distribution in the patients, compared with healthy control data, revealed some statistically significant differences, even after the more rigid Bonferoni correction (P(c)). In the patients group, the frequency of following HLA antigens was significantly increased compared with the control group: HLA-A1 (P(c): .005), HLA-A24 (P(c): .02), HLA-A32 (P(c): .01), HLA-B51 (P(c): .00001), HLA-DR1 (P(c): .02), and HLA-DR4 (P(c): .004).

Conclusion

These preliminary data suggest that brain cavernoma susceptibility may be associated with HLA antigens. Further studies should be designed to include a larger population of patients with brain cavernoma in order to expose whether there is association between HLA typing and occurrence of cavernoma more accurately."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.org/dc/terms/identifier"doi:10.1016/j.surneu.2006.10.054"xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Yilmaz E."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Sanus G.Z."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Tanriverdi T."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Kafadar A.M."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Ak H."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Canbaz B."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Hanimoglu H."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Kaynar M.Y."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/author"Ulu M.O."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/name"Surg Neurol"xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/pages"164-166"xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/title"Cerebral cavernomas and human leukocyte antigens: preliminary clinical results."xsd:string
http://purl.uniprot.org/citations/17662350http://purl.uniprot.org/core/volume"68"xsd:string
http://purl.uniprot.org/citations/17662350http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17662350
http://purl.uniprot.org/citations/17662350http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-17662350http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17662350
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