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| http://purl.uniprot.org/citations/17662718 | http://www.w3.org/2000/01/rdf-schema#comment | "Human lens beta-crystallin contains four acidic (betaA1-->betaA4) and three basic (betaB1-->betaB3) subunits. They oligomerize in the lens, but it is uncertain which subunits are involved in the oligomerization. We used a two-hybrid system to detect protein-protein interactions systematically. Proteins were also expressed for some physicochemical studies. The results indicate that all acidic-basic pairs (betaA-betaB) except betaA4-betaBs pairs show strong hetero-molecular interactions. For acidic or basic pairs, only two pairs (betaA1-betaA1 and betaA3-betaA3) show strong self-association. betaA2 and betaA4 show very weak self-association, which arises from their low solubility. Confocal fluorescence microscopy shows enormous protein aggregates in betaA2- or betaA4-crystallin transfected cells. However, coexpression with betaB2-crystallin decreased both the number and size of aggregates. Circular dichroism indicates subtle differences in conformation among beta-crystallins that may have contributed to the differences in interactions."xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.07.022"xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/author | "Liang J.J."xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/author | "Liu B.F."xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/pages | "3936-3942"xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/title | "Protein-protein interactions among human lens acidic and basic beta-crystallins."xsd:string |
| http://purl.uniprot.org/citations/17662718 | http://purl.uniprot.org/core/volume | "581"xsd:string |
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