| http://purl.uniprot.org/citations/17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17664294 | http://www.w3.org/2000/01/rdf-schema#comment | "In conditions of T lymphopenia, interleukin (IL) 7 levels rise and, via T cell receptor for antigen-self-major histocompatibility complex (MHC) interaction, induce residual naive T cells to proliferate. This pattern of lymphopenia-induced "homeostatic" proliferation is typically quite slow and causes a gradual increase in total T cell numbers and differentiation into cells with features of memory cells. In contrast, we describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo. In this situation, CD8(+) T cells undergo massive expansion and rapid differentiation into effector cells, thus closely resembling the T cell response to foreign antigens. However, the responses induced by IL-2/IL-15 are not seen in MHC-deficient hosts, implying that the responses are driven by self-ligands. Hence, homeostatic proliferation of naive T cells can be either slow or fast, with the quality of the response to self being dictated by the particular cytokine (IL-7 vs. IL-2/IL-15) concerned. The relevance of the data to the gradual transition of naive T cells into memory-phenotype (MP) cells with age is discussed."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20070740"xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Sprent J."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Kim D.M."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Hahm B."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Surh C.D."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Boyman O."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Kim H.O."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Ramsey C."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/author | "Rubinstein M.P."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/pages | "1787-1801"xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/title | "An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2."xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/17664294 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17664294 |
| http://purl.uniprot.org/citations/17664294 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17664294 |
| http://purl.uniprot.org/uniprot/#_A0A068BER1-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ8-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |
| http://purl.uniprot.org/uniprot/#_F6QHF1-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |
| http://purl.uniprot.org/uniprot/#_P01590-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |
| http://purl.uniprot.org/uniprot/#_P01731-mappedCitation-17664294 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17664294 |