| http://purl.uniprot.org/citations/17665979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17665979 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily acting as transcription factors. PPAR-gamma, one of the three PPAR subtypes, is expressed in many malignant and non-malignant cells and tissues. PPAR-gamma ligands influence cancer biology via both genomic as well as non-genomic events. The non-genomic action of PPAR-gamma ligands, including the activation of MAPK signaling pathways, is under intense investigation. In the presence of PPAR-gamma ligands, a rapid phosphorylation of ERK1/2 is observed in many cancer cell lines. Activated ERK1/2 elicits rapid, non-genomic cellular effects and can directly repress PPAR-gamma transcriptional activity by phosphorylation. This paper reviews the interrelation of PPAR-gamma ligands and activated ERK1/2, in relation to their antineoplastic actions in cancer cell lines, which may offer the potential for improved anticancer therapies."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.org/dc/terms/identifier | "doi:10.1517/14728222.11.8.1071"xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/author | "Pitulis N."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/author | "Papageorgiou E."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/author | "Lembessis P."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/author | "Koutsilieris M."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/author | "Msaouel P."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/name | "Expert Opin Ther Targets"xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/pages | "1071-1085"xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/title | "The non-genomic crosstalk between PPAR-gamma ligands and ERK1/2 in cancer cell lines."xsd:string |
| http://purl.uniprot.org/citations/17665979 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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