| http://purl.uniprot.org/citations/17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17666167 | http://www.w3.org/2000/01/rdf-schema#comment | "Smac/DIABLO, a proapoptotic protein released from mitochondrial intermembrane space during apoptosis, promotes caspases activation by IAPs neutralization. The kinetics and molecular mechanism of Smac/DIABLO release from mitochondria has remained obscure. Present study is focused on the role of Bid in the control of Bax-GFP and Smac/DIABLO-GFP kinetics in breast cancer MCF-7 cells stimulated to apoptosis with camptothecin (CPT). Minute kinetics of proteins was examined by homeostatic confocal microscopy. The release of Smac/DIABLO-GFP from mitochondria comprised two phases: initial-rapid, lasting 20-30 min and subsequent 30 min-plateau phase, followed by the decrease of Smac/DIABLO-related fluorescence due to cell destruction. The kinetics of Bax-GFP aggregation on mitochondria coincided in time with Smac/DIABLO-GFP release from these organelles. Bid knock down and Bcl-2 overexpression delayed Bax-GFP aggregation and completely inhibited Smac/DIABLO-GFP release from mitochondria. Knock down of caspase 8 (activator of Bid) delayed both Bax-GFP aggregation and Smac/DIABLO-GFP release in CPT-treated cells. In conclusion, Bid protein is crucial for the control of the release of Smac/DIABLO from mitochondria in breast cancer MCF-7 stimulated to apoptosis with CPT."xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/author | "Gorka M."xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/author | "Motyl T."xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/author | "Lamparska-Przybysz M."xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/name | "Cell Mol Biol (Noisy-le-grand) 52"xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/pages | "OL915-22"xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/title | "Impaired kinetics of Bax-GFP and Smac/DIABLO-GFP in caspase-8- and bid-silenced and Bcl-2 overexpressed breast cancer MCF-7 cells exposed to camptothecin."xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://purl.uniprot.org/core/volume | "Suppl"xsd:string |
| http://purl.uniprot.org/citations/17666167 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17666167 |
| http://purl.uniprot.org/citations/17666167 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ4-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_P10415-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_B3KT21-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A8ASI8-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ5-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ8-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQR6-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V3S7-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A0A2P1N6U0-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_A9QXG9-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_B1PL87-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_B2ZP78-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |
| http://purl.uniprot.org/uniprot/#_B2ZP79-mappedCitation-17666167 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666167 |