| http://purl.uniprot.org/citations/17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17666529 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional control by beta-catenin and lymphoid enhancer-binding factor 1 (LEF1)/T cell factor regulates proliferation in stem cells and tumorigenesis. Here we provide evidence that transcriptional co repressor homeodomain interacting protein kinase 2 (HIPK2) controls the number of stem and progenitor cells in the skin and the susceptibility to develop squamous cell carcinoma. Loss of HIPK2 leads to increased proliferative potential, more rapid G1-S transition in cell cycle, and expansion of the epidermal stem cell compartment. Among the critical regulators of G1-S transition in the cell cycle, only cyclin D1 is selectively up-regulated in cells lacking HIPK2. Conversely, overexpression of HIPK2 suppresses LEF1/beta-catenin-mediated transcriptional activation of cyclin D1 expression. However, deletion of the C-terminal YH domain of HIPK2 completely abolishes its ability to recruit another transcriptional corepressor CtBP and suppress LEF1/beta-catenin-mediated transcription. To determine whether loss of HIPK2 leads to increased susceptibility to tumorigenesis, we treat wild-type, Hipk2+/-, andHipk2-/-mice with the two-stage carcinogenesis protocol. Our results indicate that more skin tumors are induced in Hipk2+/- and Hipk2-/-mutants, with most of the tumors showing shortened incubation time and malignant progression. Together, our results indicate that HIPK2 is a tumor suppressor that controls proliferation by antagonizing LEF1/beta-catenin-mediated transcription. Loss of HIPK2 synergizes with activation of H-ras to induce tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0703213104"xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Appella E."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Wei G."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Saito S."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Huang E.J."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Balmain A."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Mao J.H."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Tang A.A."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Ku S."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/author | "Ma G.K."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/pages | "13040-13045"xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/title | "HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17666529 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17666529 |
| http://purl.uniprot.org/citations/17666529 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17666529 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666529 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666529 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666529 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J202-mappedCitation-17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666529 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J204-mappedCitation-17666529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17666529 |