| http://purl.uniprot.org/citations/17668061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17668061 | http://www.w3.org/2000/01/rdf-schema#comment | "Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. We previously reported that the cysteine protease cathepsin K (ctsk) is overexpressed in the white adipose tissue (WAT) of obese individuals. We herein characterized the WAT and the metabolic phenotype of ctsk deficient animals (ctsk-/-). When the growth rate of ctsk-/-was compared to that of the wild type animals (WT), we could establish a time window (5-8 weeks of age) within which ctsk-/-display significantly lower body weight and WAT size as compared to WT. Such a difference was not observable in older mice. Upon treatment with high fat diet (HFD) for 12 weeks ctsk-/-gained significantly less weight than WT and showed reduced brown adipose tissue, liver mass and a lower percentage of body fat. Plasma triglycerides, cholesterol and leptin were significantly lower in HFD-fed-ctsk-/-as compared to HFD-fed WT animals. Adipocyte lipolysis rates were increased in both young and HFD-fed-ctsk-/-, as compared to WT. Carnitine palmitoyl transferase-1 activity, was higher in mitochondria isolated from the WAT of HFD treated ctsk-/-as compared to WT. Together, these data indicate that ctsk ablation in mice results in reduced body fat content under conditions requiring a rapid accumulation of fat stores. This observation could be partly explained by an increased release and/or utilization of FFA and by an augmented ratio of lipolysis/lipogenesis. These results also demonstrate that under a HFD, ctsk deficiency confers a partial resistance to the development of dyslipidemia."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0000683"xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Morin N."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Saftig P."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Chiellini C."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Pinchera A."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Santini F."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Desmarais S."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Maffei M."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Novelli M."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Mancini J."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Percival M.D."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Boschi F."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Vottari T."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Cocuzza C."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Masiello P."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Ragni M."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Funicello M."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Marzola P."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "Soriano-Lopez J."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/author | "St-Jacques R."xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/17668061 | http://purl.uniprot.org/core/pages | "e683"xsd:string |