| http://purl.uniprot.org/citations/17668902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17668902 | http://www.w3.org/2000/01/rdf-schema#comment | "The CXCL10 chemokine is a critical chemoattractant for the recruitment of activated Th1 and NK cells into inflammatory sites. CXCL10 is typically produced by myeloid cells in response to IFN-gamma, as well as by neutrophils, though the latter require a costimulation with IFN-gamma and LPS. In this study, we investigated the molecular mechanism(s) whereby IFN-gamma and TLR4 ligation synergize to induce CXCL10 expression in neutrophils. By primary transcript real-time PCR analysis, we demonstrate that the CXCL10 gene is transcriptionally induced by the LPS plus IFN-gamma combination in neutrophils, consistent with previous studies showing that increased CXCL10 gene expression does not reflect enhanced mRNA stability. The IFN-gamma-induced STAT1 activation and the lipopolysaccharide (LPS)-induced NF-kappaB activation were not enhanced if neutrophils were exposed to both stimuli, whereas both transcription factors were activated by IFN-gamma or LPS in monocytes. Finally, pharmacological inhibitors of NF-kappaB demonstrated its role in the induction of CXCL10 expression by LPS plus IFN-gamma in neutrophils, and by LPS or IFN-gamma in monocytes. Together, these results suggest that in neutrophils, the synergy observed between LPS and IFN-gamma toward CXCL10 gene expression likely reflects the cooperative induction of the NF-kappaB and STAT1 transcription factors by LPS and IFN-gamma, respectively."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737340"xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Cloutier A."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Bazzoni F."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Gasperini S."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Cassatella M.A."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Calzetti F."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "McDonald P.P."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Ear T."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/author | "Tamassia N."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/pages | "2627-2634"xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/title | "Molecular mechanisms underlying the synergistic induction of CXCL10 by LPS and IFN-gamma in human neutrophils."xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/17668902 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17668902 |
| http://purl.uniprot.org/citations/17668902 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17668902 |
| http://purl.uniprot.org/uniprot/#_P02778-mappedCitation-17668902 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17668902 |
| http://purl.uniprot.org/uniprot/P02778 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17668902 |