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| http://purl.uniprot.org/citations/17669273 | http://www.w3.org/2000/01/rdf-schema#comment | "Soluble or cell-bound IL-1 receptor accessory protein (IL-1RAcP) does not bind IL-1 but rather forms a complex with IL-1 and IL-1 receptor type I (IL-1RI) resulting in signal transduction. Synthetic peptides to various regions in the Ig-like domains of IL-1RAcP were used to produce antibodies and these antibodies were affinity-purified using the respective antigens. An anti-peptide-4 antibody which targets domain III inhibited 70% of IL-1beta-induced productions of IL-6 and PGE(2) from 3T3-L1 cells. Anti-peptide-2 or 3 also inhibited IL-1-induced IL-6 production by 30%. However, anti-peptide-1 which is directed against domain I had no effect. The antibody was more effective against IL-1beta compared to IL-1alpha. IL-1-induced IL-6 production was augmented by coincubation with PGE(2). The COX inhibitor ibuprofen blocked IL-1-induced IL-6 and PGE(2) production. These results confirm that IL-1RAcP is essential for IL-1 signaling and that increased production of IL-6 by IL-1 needs the co-induction of PGE(2). However, the effect of PGE(2) is independent of expressions of IL-1RI and IL-1RAcP. Our data suggest that domain III of IL-1RAcP may be involved in the formation or stabilization of the IL-1RI/IL-1 complex by binding to epitopes on domain III of the IL-1RI created following IL-1 binding to the IL-1RI."xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.org/dc/terms/identifier | "doi:10.5483/bmbrep.2007.40.4.562"xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/author | "Yoon D.Y."xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/author | "Dinarello C.A."xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/name | "J Biochem Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/pages | "562-570"xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/title | "Differential effects of anti-IL-1R accessory protein antibodies on IL-1alpha or IL-1beta-induced production of PGE(2) and IL-6 from 3T3-L1 cells."xsd:string |
| http://purl.uniprot.org/citations/17669273 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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