| http://purl.uniprot.org/citations/17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17671182 | http://www.w3.org/2000/01/rdf-schema#comment | "The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. Previous studies showed that the expression of KLF4 was activated by the colorectal cancer tumor suppressor adenomatous polyposis coli (APC) and that KLF4 repressed the Wnt/beta-catenin pathway. Here, we examined whether KLF4 plays a role in modulating intestinal tumorigenesis by comparing the tumor burdens in mice heterozygous for the Apc(Min) allele (Apc(Min/+)) and those heterozygous for both the Apc(Min) and Klf4 alleles (Klf4(+/-)/Apc(Min/+)). Between 10 and 20 weeks of age, Klf4(+/-)/Apc(Min/+) mice developed, on average, 59% more intestinal adenomas than Apc(Min/+) mice (P < 0.0001). Immunohistochemical staining showed that Klf4 protein levels were lower in the normal-appearing intestinal tissues of Klf4(+/-)/Apc(Min/+) mice compared with wild-type, Klf4(+/-), or Apc(Min/+) mice. In contrast, the levels of beta-catenin and cyclin D1 were higher in the normal-appearing intestinal tissues of Klf4(+/-)/Apc(Min/+) mice compared with the other three genotypes. Klf4 levels were further decreased in adenomas from both Apc(Min/+) and Klf4(+/-)/Apc(Min/+) mice compared with their corresponding normal-appearing tissues. Reverse transcription-PCR showed an inverse correlation between adenoma size and Klf4 mRNA levels in both Klf4(+/-)/Apc(Min/+) and Apc(Min/+) mice. There was also a progressive loss of heterozygosity of the wild-type Apc allele in adenomas with increasing size from Klf4(+/-)/Apc(Min/+) and Apc(Min/+) mice. Results from this study show that KLF4 plays an important role in promoting the development of intestinal adenomas in the presence of Apc(Min) mutation."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-1302"xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "Yang V.W."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "Kaestner K.H."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "McConnell B.B."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "Katz J.P."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "Nandan M.O."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/author | "Ghaleb A.M."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/pages | "7147-7154"xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/title | "Haploinsufficiency of Kruppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17671182 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17671182 |
| http://purl.uniprot.org/citations/17671182 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17671182 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-4E16FAB2BF2C8D22EE4D417A551A6DCA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/Q60793#attribution-6B1ADC0867B5C453EE6FC98D378B885C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_B7ZCH1-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |
| http://purl.uniprot.org/uniprot/#_B7ZCH2-mappedCitation-17671182 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17671182 |