| http://purl.uniprot.org/citations/17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17675465 | http://www.w3.org/2000/01/rdf-schema#comment | "Various signals during infection influence CD8 T cell memory generation, but these factors have yet to be fully defined. IL-12 is a proinflammatory cytokine that has been shown to enhance IFN-gamma-producing T cell responses and has been widely tested as a vaccine adjuvant. In this study, we show that IL-12-deficient mice generate a weaker primary CD8 T cell response and are more susceptible to Listeria monocytogenes infection, but have substantially more memory CD8 T cells and greater protective immunity against reinfection. Kinetic analyses show that in the absence of IL-12 there is a reduced contraction of Ag-specific CD8 T cells and a gradual increase in memory CD8 T cells as a result of increased homeostatic renewal. By signaling directly through its receptor on CD8 T cells, IL-12 influences their differentiation to favor the generation of fully activated effectors, but hinders the formation of CD8 T cell memory precursors and differentiation of long-term CD8 T cell memory(.) These results have implications for understanding memory T cell development and enhancing vaccine efficacy, and offer new insight into the role of IL-12 in coordinating the innate and adaptive immune response."xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.4.2074"xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/author | "Pearce E.L."xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/pages | "2074-2081"xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/title | "Generation of CD8 T cell memory is regulated by IL-12."xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17675465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17675465 |
| http://purl.uniprot.org/citations/17675465 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17675465 |
| http://purl.uniprot.org/uniprot/#_D3Z6H5-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_F8WI71-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_Q3ZAX5-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_P43431-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_P43432-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_P97378-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_Q549G3-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/#_Q9QUT1-mappedCitation-17675465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/P43431 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/Q549G3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/P97378 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/D3Z6H5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17675465 |
| http://purl.uniprot.org/uniprot/P43432 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17675465 |