| http://purl.uniprot.org/citations/17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17675501 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains pleckstrin homology- and Src homology 2-like domains as well as a YXXQ motif in its C-terminal region. Our previous studies demonstrated that STAP-2 binds to STAT3 and STAT5, and regulates their signaling pathways. In the present study, we find that STAP-2-deficient splenocytes or T cells exhibit enhanced cell adhesion to fibronectin after PMA treatment, and that STAP-2-deficient T cells contain the increased protein contents of focal adhesion kinase (FAK). Furthermore, overexpression of STAP-2 induces a dramatic decrease in the protein contents of FAK and integrin-mediated T cell adhesion to fibronectin in Jurkat T cells via the degradation of FAK. Regarding the mechanism for this effect, we found that STAP-2 associates with FAK and enhances its degradation, proteasome inhibitors block FAK degradation, and STAP-2 recruits an endogenous E3 ubiquitin ligase, Cbl, to FAK. These results reveal a novel regulation mechanism for integrin-mediated signaling in T cells via STAP-2, which directly interacts with and degrades FAK."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.179.4.2397"xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Tsuji S."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Ohbayashi N."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Ikeda O."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Shimoda K."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/author | "Sugiyma K."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/pages | "2397-2407"xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/title | "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase."xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://purl.uniprot.org/core/volume | "179"xsd:string |
| http://purl.uniprot.org/citations/17675501 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17675501 |
| http://purl.uniprot.org/citations/17675501 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17675501 |
| http://purl.uniprot.org/uniprot/#_A0A087WQE0-mappedCitation-17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675501 |
| http://purl.uniprot.org/uniprot/#_A0A087WS56-mappedCitation-17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675501 |
| http://purl.uniprot.org/uniprot/#_A0A087WS99-mappedCitation-17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675501 |
| http://purl.uniprot.org/uniprot/#_A0A087WSN6-mappedCitation-17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675501 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP17-mappedCitation-17675501 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17675501 |