| http://purl.uniprot.org/citations/17678725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17678725 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the contribution of the tumor necrosis factor alpha gene (TNFA) to the immunogenetic risk prediction of type 1 diabetes (T1D) in the Belgian population, well-characterized antibody-positive patients with type 1 diabetes (T1D), nondiabetic control subjects, and nuclear families were analyzed for HLA-DQA1-DQB1, TNFA -308 G/A promoter single nucleotide polymorphism (SNP) and TNFa microsatellite markers in both case-control and transmission studies. A total of 1,029 patients (mean age at onset, 18 years; male/female ratio, 1.2), 575 control subjects and 179 nuclear families were analyzed for the -308 SNP and 1,082 patients (mean age at onset, 17 years; and male/female ratio, 1.3), 606 control subjects, and 261 nuclear families were analyzed for the TNFa microsatellite marker. All subjects were typed initially for HLA-DQ. No primary association was detected with the -308 G/A promoter SNP. In contrast, we found evidence of a contribution of TNFa1 allele to susceptibility for T1D independently of HLA-DQ. We observed that the conserved HLA-DQ-TNFa extended haplotype, HLA-DQA1 0501-DQB1 0201-TNFa1 is a diabetogenic haplotype in the Belgian population and is independent of age at onset and gender and confers an estimated relative risk of 4.55 and an absolute risk of 1.7%. In conclusion, our observations suggest that the-308 G/A promoter SNP is not a genetic marker for T1D, but that the TNFa microsatellite may have an added value to further refine the immunogenetic risk conferred by the HLA-DQ region in the Belgian population."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.humimm.2007.05.001"xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Quartier E."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Koeleman B.P."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Gorus F.K."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Van Autreve J.E."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Van der Auwera B.J."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Aminkeng F."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/author | "Van Schravendijk C."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/pages | "690-697"xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/title | "TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ."xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/17678725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17678725 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C853-mappedCitation-17678725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17678725 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7CAE0-mappedCitation-17678725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17678725 |
| http://purl.uniprot.org/uniprot/#_A0A0A7CAE6-mappedCitation-17678725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17678725 |