| http://purl.uniprot.org/citations/17679093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17679093 | http://www.w3.org/2000/01/rdf-schema#comment | "Both microRNAs and alternative pre-mRNA splicing have been implicated in the development of the nervous system (NS), but functional interactions between these two pathways are poorly understood. We demonstrate that the neuron-specific microRNA miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in nonneuronal cells. Among the targets of PTBP1 is a critical cassette exon in the pre-mRNA of PTBP2 (nPTB/brPTB/PTBLP), an NS-enriched PTBP1 homolog. When this exon is skipped, PTBP2 mRNA is subject to nonsense-mediated decay (NMD). During neuronal differentiation, miR-124 reduces PTBP1 levels, leading to the accumulation of correctly spliced PTBP2 mRNA and a dramatic increase in PTBP2 protein. These events culminate in the transition from non-NS to NS-specific alternative splicing patterns. We also present evidence that miR-124 plays a key role in the differentiation of progenitor cells to mature neurons. Thus, miR-124 promotes NS development, at least in part by regulating an intricate network of NS-specific alternative splicing."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.07.015"xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/author | "Maniatis T."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/author | "Makeyev E.V."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/author | "Carrasco M.A."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/pages | "435-448"xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/title | "The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing."xsd:string |
| http://purl.uniprot.org/citations/17679093 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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