| http://purl.uniprot.org/citations/17679095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17679095 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17679095 | http://www.w3.org/2000/01/rdf-schema#comment | "Cbl proteins are E3 ubiquitin ligases that are negative regulators of many receptor tyrosine kinases. Cbl-b and c-Cbl contain a ubiquitin-associated (UBA) domain, which is present in a variety of proteins involved in ubiquitin-mediated processes. Despite high sequence identity, Cbl UBA domains display remarkably different ubiquitin-binding properties. Here, we report the crystal structure of the UBA domain of Cbl-b in complex with ubiquitin at 1.9 A resolution. The structure reveals an atypical mechanism of ubiquitin recognition by the first helix of the UBA. Helices 2 and 3 of the UBA domain form a second binding surface, which mediates UBA dimerization in the crystal and in solution. Site-directed mutagenesis demonstrates that Cbl-b dimerization is regulated by ubiquitin binding and required for tyrosine phosphorylation of Cbl-b and ubiquitination of Cbl-b substrates. These studies demonstrate a role for ubiquitin in regulating biological activity by promoting protein dimerization."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.06.023"xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2007.06.023"xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Berghuis A.M."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Berghuis A.M."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Lin T."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Lin T."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Gehring K."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Gehring K."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Kozlov G."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Kozlov G."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Mirza I.A."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Mirza I.A."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Peschard P."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/author | "Peschard P."xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/17679095 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |