DESCRIBE <http://purl.uniprot.org/citations/17681175>

Subject	Predicate	Object
http://purl.uniprot.org/citations/17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17681175	http://www.w3.org/2000/01/rdf-schema#comment	" Background and aims The transcription factor SOX9 has been shown previously to have an essential role in the differentiation of a small number of discrete cell lineages. In the intestine, Sox9 is expressed in the epithelial cells of the crypts and is a target of Wnt signaling. Methods To examine the function of SOX9 in the intestine, we inactivated the Sox9 gene in intestinal epithelial cells by generating mice that harbored a conditional Sox9 gene and a Villin-Cre transgene. Results In the absence of SOX9, Paneth cells were not formed, but the differentiation of other intestinal epithelial cell types was unaffected. The lack of SOX9 also lead to crypt enlargement, to a marked increase in cell proliferation throughout the crypts, and to replacement of the Paneth cells by proliferating epithelial cells. Conclusions We conclude that SOX9 is required for the differentiation of Paneth cells. Our results elucidate an essential step in the differentiation of gut epithelium."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.org/dc/terms/identifier	"doi:10.1053/j.gastro.2007.05.020"xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"Zhang J."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"Clevers H."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"Hamilton S.R."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"Adams H.P."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"de Crombrugghe B."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"van Es J.H."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"van den Born M."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/author	"Mori-Akiyama Y."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/date	"2007"xsd:gYear
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/name	"Gastroenterology"xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/pages	"539-546"xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/title	"SOX9 is required for the differentiation of paneth cells in the intestinal epithelium."xsd:string
http://purl.uniprot.org/citations/17681175	http://purl.uniprot.org/core/volume	"133"xsd:string
http://purl.uniprot.org/citations/17681175	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/17681175
http://purl.uniprot.org/citations/17681175	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/17681175
http://purl.uniprot.org/uniprot/Q04887#attribution-0221D5EA982D321A2A04D1F3837179FB	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_A0A1B0GQV9-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175
http://purl.uniprot.org/uniprot/#_A4FUR8-mappedCitation-17681175	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17681175