| http://purl.uniprot.org/citations/17685927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17685927 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylation of checkpoint kinase 2 (Chk2) at Thr68 (pChk2) induced by DNA double-strand breaks is required for inhibition of cell cycle progression in the G(2) phase. The purpose of the present paper was to investigate the expression of wild-type p53-induced phosphatase 1 (Wip1 or PPM1D), a negative regulator of Chk2, to better understand its role in human gastric cancer. In non-neoplastic gastric mucosa, most epithelial cells exhibited Wip1-positive and pChk2-negative immunoreactivity, whereas an inverse pattern of protein expression was detected at the surface of the foveolar epithelium. In tumor tissues, 74% of 53 gastric cancers had intense Wip1 immunoreactivity and close correlation with both tumor size (P = 0.0497) and Chk2 dephosphorylation (P = 0.0213). In MKN-74 gastric cancer cells, ionizing radiation (IR)-induced Wip1 upregulation was detected at protein levels, but the Chk2-mediated cell cycle regulatory mechanism was disrupted. In addition, protease inhibitor Z-Leu-Leu-Leu (ZLLL) effectively upregulated Wip1 levels in the presence or absence of IR, suggesting that Wip1 expression can be modulated post-transcriptionally. Understanding the Wip1-mediated signaling pathway in gastric cancer may provide useful information for the development of new chemo- and radiotherapies."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1440-1827.2007.02140.x"xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/author | "Semba S."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/author | "Yokozaki H."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/author | "Fuku T."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/author | "Yutori H."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/name | "Pathol Int"xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/pages | "566-571"xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/title | "Increased wild-type p53-induced phosphatase 1 (Wip1 or PPM1D) expression correlated with downregulation of checkpoint kinase 2 in human gastric carcinoma."xsd:string |
| http://purl.uniprot.org/citations/17685927 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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