| http://purl.uniprot.org/citations/17689858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17689858 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytotoxic effect of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is limited in some cancer cells, including AGS gastric adenocarcinoma cells. However, treatment with TRAIL in combination with subtoxic concentrations of genistein sensitizes TRAIL-resistant AGS cells to TRAIL-mediated apoptosis. Combined treatment with genistein and TRAIL-induced chromatin condensation and sub-G1 phase DNA content. These indicators of apoptosis are correlated with the activation of death receptors (DR5) and induction of caspase-3 activity, which results in the cleavage of poly(ADP-ribose)polymerase. Both the cytotoxic effect and apoptotic characteristics induced by combined treatment were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor, which demonstrates the important role of caspase-3 in the observed cytotoxic effect. These results indicate that caspase-3 is a key regulator of apoptosis in response to combined genistein and TRAIL in human gastric adenocarcinoma AGS cells through the activation of DR5 and mitochondrial dysfunction."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2007.06.019"xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Choi Y.H."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Lee W.H."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Lee T.H."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Kim G.Y."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Lee J.D."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Cheong J."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Ryu C.H."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Choi B.T."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/author | "Jin C.Y."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/pages | "56-64"xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/title | "Genistein sensitizes TRAIL-resistant human gastric adenocarcinoma AGS cells through activation of caspase-3."xsd:string |
| http://purl.uniprot.org/citations/17689858 | http://purl.uniprot.org/core/volume | "257"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B7Z588-mappedCitation-17689858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17689858 |