| http://purl.uniprot.org/citations/17689978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17689978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17689978 | http://www.w3.org/2000/01/rdf-schema#comment | "Heptaspanning membrane also known as G protein-coupled receptors (GPCR) do interact with a variety of intracellular proteins whose function is regulate receptor traffic and/or signaling. Using a yeast two-hybrid screen, NECAB2, a neuronal calcium binding protein, was identified as a binding partner for the adenosine A(2A) receptor (A(2A)R) interacting with its C-terminal domain. Co-localization, co-immunoprecipitation and pull-down experiments showed a close and specific interaction between A(2A)R and NECAB2 in both transfected HEK-293 cells and also in rat striatum. Immunoelectron microscopy detection of NECAB2 and A(2A)R in the rat striatopallidal structures indicated that both proteins are co-distributed in the same glutamatergic nerve terminals. The interaction of NECAB2 with A(2A)R modulated the cell surface expression, the ligand-dependent internalization and the receptor-mediated activation of the MAPK pathway. Overall, these results show that A(2A)R interacts with NECAB2 in striatal neurones co-expressing the two proteins and that the interaction is relevant for A(2A)R function."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2007.05.007"xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2007.05.007"xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Lluis C."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Lluis C."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Burgueno J."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Burgueno J."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Canela E.I."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Canela E.I."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Canela L."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Canela L."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Ciruela F."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Ciruela F."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Franco R."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Franco R."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Lujan R."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Mallol J."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/author | "Mallol J."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17689978 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |