| http://purl.uniprot.org/citations/17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17690314 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveWhereas estradiol prevents fatty streak deposit in immunocompetent apoE-/- or LDLr-/-mice, it is totally ineffective in immunodeficient mice, underlining the key role of immunoinflammation in this effect. In the present work, the role of several major pro- and antiinflammatory cytokines involved in the atheromatous process was evaluated in the effect of estradiol on fatty streak constitution.Methods and resultsThe preventive effect of estradiol was fully maintained in LDLr-/-mice grafted with bone marrow from either IFN-gamma or interleukin (IL)-12-deficient mice, showing that this beneficial effect was not mediated through a specific decrease in the production of these 2 proinflammatory cytokines. Furthermore, IL-10-/- apoE-/-mice remained protected by estradiol, excluding a significant contribution of this antiinflammatory cytokine. In contrast, the protective effect of estradiol was (1) associated with enhanced aortic expression of TGF-beta1 in apoE-/-mice during early steps of atherogenesis; (2) abolished and even reversed in apoE-/-mice administered with a neutralizing anti-TGF-beta antibody; (3) abolished in LDLr-/-mice grafted with bone marrow from Smad3-deficient mice.ConclusionsThe status of the TGF-beta pathway crucially determines the antiatherogenic effect of estradiol in hypercholesterolemic mice, whereas neither IFN-gamma, IL-12, nor IL-10 are specifically involved in this protection."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.org/dc/terms/identifier | "doi:10.1161/atvbaha.107.150300"xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Terce F."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Schambourg A."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Arnal J.F."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Bayard F."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Gourdy P."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Garmy-Susini B."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Douin-Echinard V."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Filipe C."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/author | "Calippe B."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/name | "Arterioscler Thromb Vasc Biol"xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/pages | "2214-2221"xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/title | "Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice."xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17690314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17690314 |
| http://purl.uniprot.org/citations/17690314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17690314 |
| http://purl.uniprot.org/uniprot/#_E9Q6I6-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |
| http://purl.uniprot.org/uniprot/#_A2CG44-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |
| http://purl.uniprot.org/uniprot/#_A2CG45-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |
| http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-17690314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17690314 |