| http://purl.uniprot.org/citations/17692540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17692540 | http://www.w3.org/2000/01/rdf-schema#comment | "The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable T cell function remains unclear. Here, we report that T cells lacking both Bax and Bak display defects in antigen-specific proliferation because of Ca(2+)-signaling defects. Bax(-/-), Bak(-/-) T cells displayed defective T cell receptor (TCR)- and inositol-1,4,5-trisphosphate (IP(3))-dependent Ca(2+) mobilization because of altered endoplasmic reticulum (ER) Ca(2+) regulation that was reversed by Bax's reintroduction. The ability of TCR-dependent Ca(2+) signals to stimulate mitochondrial NADH production in excess of that utilized for ATP synthesis was dependent on Bax and Bak. Blunting of Ca(2+)-induced mitochondrial NADH elevation in the absence of Bax and Bak resulted in decreased reactive-oxygen-species production, which was required for T cell proliferation. Together, the data establish that Bax and Bak play an essential role in the control of T cell proliferation by modulating ER Ca(2+) release."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2007.05.023"xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Lindsten T."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Foskett J.K."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Jones R.G."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Kubek S."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Madesh M."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Wang Y.L."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Conway S.J."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "White C."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Bootman M.D."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Roderick H.L."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Krawczyk C.M."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Bui T."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Frauwirth K.A."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/author | "Hawkins B.J."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/pages | "268-280"xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/title | "The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis."xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17692540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17692540 |