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http://purl.uniprot.org/citations/17693780http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17693780http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis.

Methods

Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay.

Results

Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%.

Conclusion

Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.org/dc/terms/identifier"doi:10.1097/jom.0b013e318124a927"xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Chen L."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Guo Y."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Liu P."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Wang S.X."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Wang R.Y."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Wei M.T."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Liang X.C."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/author"Tu Z.G."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/name"J Occup Environ Med"xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/pages"834-839"xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/title"Roles of serum clara cell protein 16 and surfactant protein-D in the early diagnosis and progression of silicosis."xsd:string
http://purl.uniprot.org/citations/17693780http://purl.uniprot.org/core/volume"49"xsd:string
http://purl.uniprot.org/citations/17693780http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17693780
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http://purl.uniprot.org/uniprot/#_P35247-mappedCitation-17693780http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17693780
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http://purl.uniprot.org/uniprot/P11684http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17693780
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