| http://purl.uniprot.org/citations/17694060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17694060 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17694060 | http://www.w3.org/2000/01/rdf-schema#comment | "All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1502"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1502"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Feng D."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Feng D."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Garcia K.C."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Ely L.K."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Ely L.K."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Bond C.J."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Bond C.J."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Maynard J."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/author | "Maynard J."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/pages | "975-983"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/pages | "975-983"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/title | "Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/title | "Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'."xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/17694060 | http://purl.uniprot.org/core/volume | "8"xsd:string |