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http://purl.uniprot.org/citations/17695523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17695523http://www.w3.org/2000/01/rdf-schema#comment"

Background

DARPP-32 is a neuronal protein that plays a central role in dopaminergic neurotransmission. Although DARPP-32 may contribute to the pathogenesis of several human malignancies, its expression has never been investigated in oral premalignant and malignant lesions.

Materials and methods

DARPP-32 expression was examined using immunohistochemistry in 14 normal oral mucosa, 5 normal lower lip mucosa, 41 oral leukoplakia (OL), 30 oral squamous cell carcinoma (OSCC) and 20 lower lip squamous cell carcinoma (LLSCC) specimens. Differences of its expression between groups were analyzed.

Results

OSCC and OL with moderate or severe dysplasia showed lower DARPP-32 expression in relation to normal oral mucosa. LLSCC showed lower DARPP-32 expression than normal lower lip mucosa and OSSC.

Conclusion

The decreased expression of DARPP-32 in oral premalignant and malignant lesions suggests a tumor suppressor role for this protein in the tumorigenesis of these lesions."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"De Marco L."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"Gomez R.S."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"Romano-Silva M.A."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"Horta M.C."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"Pimenta F.J."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"De Souza B.R."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/author"Vidigal P.V."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/pages"2339-2343"xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/title"Decreased expression of DARPP-32 in oral premalignant and malignant lesions."xsd:string
http://purl.uniprot.org/citations/17695523http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/17695523http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17695523
http://purl.uniprot.org/citations/17695523http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17695523
http://purl.uniprot.org/uniprot/#_B3KVQ9-mappedCitation-17695523http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17695523
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http://purl.uniprot.org/uniprot/#_Q9UD71-mappedCitation-17695523http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17695523
http://purl.uniprot.org/uniprot/Q9NNW1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17695523
http://purl.uniprot.org/uniprot/Q9UD71http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17695523
http://purl.uniprot.org/uniprot/B3KVQ9http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17695523