| http://purl.uniprot.org/citations/17698606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17698606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17698606 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin A/Cdk2 plays an important role during S and G2/M phases of the eukaryotic cell cycle, but the mechanisms by which it regulates cell cycle events are not fully understood. We have biochemically purified and identified SCAPER, a novel protein that specifically interacts with cyclin A/Cdk2 in vivo. Its expression is cell cycle independent, and it associates with cyclin A/Cdk2 at multiple phases of the cell cycle. SCAPER localizes primarily to the endoplasmic reticulum. Ectopic expression of SCAPER sequesters cyclin A from the nucleus and results specifically in an accumulation of cells in M phase of the cell cycle. RNAi-mediated depletion of SCAPER decreases the cytoplasmic pool of cyclin A and delays the G1/S phase transition upon cell cycle re-entry from quiescence. We propose that SCAPER represents a novel cyclin A/Cdk2 regulatory protein that transiently maintains this kinase in the cytoplasm. SCAPER could play a role in distinguishing S phase- from M phase-specific functions of cyclin A/Cdk2."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701166"xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701166"xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Dynlacht B.D."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Sanchez I."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Sanchez I."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Tsang W.Y."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/author | "Tsang W.Y."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/pages | "621-633"xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/pages | "621-633"xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/title | "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/title | "SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/17698606 | http://purl.uniprot.org/core/volume | "178"xsd:string |