| http://purl.uniprot.org/citations/17699606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17699606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17699606 | http://www.w3.org/2000/01/rdf-schema#comment | "The GLHs (germline RNA helicases) are constitutive components of the germline-specific P granules in the nematode Caenorhabditis elegans and are essential for fertility, yet how GLH proteins are regulated remains unknown. KGB-1 and CSN-5 are both GLH binding partners, previously identified by two-hybrid interactions. KGB-1 is a MAP kinase in the Jun N-terminal kinase (JNK) subfamily, whereas CSN-5 is a subunit of the COP9 signalosome. Intriguingly, although loss of either KGB-1 or CSN-5 results in sterility, their phenotypes are strikingly different. Whereas csn-5 RNA interference (RNAi) results in under-proliferated germlines, similar to glh-1/glh-4(RNAi), the kgb-1(um3) loss-of-function mutant exhibits germline over-proliferation. When kgb-1(um3) mutants are compared with wild-type C. elegans, GLH-1 protein levels are as much as 6-fold elevated and the organization of GLH-1 in P granules is grossly disrupted. A series of additional in vivo and in vitro tests indicates that KGB-1 and CSN-5 regulate GLH-1 levels, with GLH-1 targeted for proteosomal degradation by KGB-1 and stabilized by CSN-5. We propose the ;good cop: bad cop' team of CSN-5 and KGB-1 imposes a balance on GLH-1 levels, resulting in germline homeostasis. In addition, both KGB-1 and CSN-5 bind Vasa, a Drosophila germ granule component; therefore, similar regulatory mechanisms might be conserved from worms to flies."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.005181"xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.005181"xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Kuzmin E."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Kuzmin E."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "McEwen T.J."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "McEwen T.J."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Orsborn A.M."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/author | "Orsborn A.M."xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/pages | "3383-3392"xsd:string |
| http://purl.uniprot.org/citations/17699606 | http://purl.uniprot.org/core/pages | "3383-3392"xsd:string |