| http://purl.uniprot.org/citations/17699774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17699774 | http://www.w3.org/2000/01/rdf-schema#comment | "L1-CAM, a neuronal cell adhesion receptor, is also expressed in a variety of cancer cells. Recent studies identified L1-CAM as a target gene of beta-catenin-T-cell factor (TCF) signaling expressed at the invasive front of human colon cancer tissue. We found that L1-CAM expression in colon cancer cells lacking L1-CAM confers metastatic capacity, and mice injected in their spleen with such cells form liver metastases. We identified ADAM10, a metalloproteinase that cleaves the L1-CAM extracellular domain, as a novel target gene of beta-catenin-TCF signaling. ADAM10 overexpression in colon cancer cells displaying endogenous L1-CAM enhanced L1-CAM cleavage and induced liver metastasis, and ADAM10 also enhanced metastasis in colon cancer cells stably transfected with L1-CAM. DNA microarray analysis of genes induced by L1-CAM in colon cancer cells identified a cluster of genes also elevated in a large set of human colon carcinoma tissue samples. Expression of these genes in normal colon epithelium was low. These results indicate that there is a gene program induced by L1-CAM in colon cancer cells that is also present in colorectal cancer tissue and suggest that L1-CAM can serve as target for colon cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-07-0991"xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Barany F."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Brabletz T."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Spaderna S."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Domany E."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Sheffer M."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Raveh S."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Shtutman M."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Gavert N."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Notterman D."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/author | "Paty P."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/pages | "7703-7712"xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/title | "Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis."xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://purl.uniprot.org/core/volume | "67"xsd:string |
| http://purl.uniprot.org/citations/17699774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17699774 |
| http://purl.uniprot.org/citations/17699774 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17699774 |
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| http://purl.uniprot.org/uniprot/#_A0AV88-mappedCitation-17699774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17699774 |
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| http://purl.uniprot.org/uniprot/#_P32004-mappedCitation-17699774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17699774 |