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http://purl.uniprot.org/citations/17701131http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17701131http://www.w3.org/2000/01/rdf-schema#comment"

Background

The clinical features of hepatitis C virus (HCV) carriers with persistently normal alanine aminotransferase (PNALT) levels (ALT < or = 34 IU/l) have not been fully elucidated. We investigated clinical factors associated with ALT flare-up in PNALT individuals in a HCV hyperendemic area of Japan.

Methods

We analyzed 101 HCV carriers who had PNALT between 1993 and 2000. The first occurrence of ALT flare-up (ALT > or = 35 IU/l) between 2001 and 2005 was evaluated by the Kaplan-Meier method. Multivariate analysis of factors predicting ALT flare-up were conducted using Cox proportional hazards models.

Results

The mean follow-up period was 2.8 years, and the 5-year cumulative incidence of ALT flare-up was estimated to be 31.8%. In multivariate analysis, an ALT level of 20-34 IU/l and a high serum ferritin level (> or =90 ng/ml) in the most recently available data up to the year 2000, as well as H63D heterozygosity in the HFE gene, were independently and strongly associated with the incidence of ALT flare-up (Hazard ratios = 5.6, 3.1, and 4.8, respectively). In addition, HFE H63D heterozygosity was significantly associated with higher serum ferritin levels in subjects with PNALT (153.8 + or - 73.3 ng/ml in subjects with the 63HD genotype vs. 89.4 + or - 51.3 ng/ml in subjects with the 63HH genotype, P = 0.043).

Conclusions

HCV carriers with PNALT in this population were at risk for ALT flare-up. Basal ALT levels, serum ferritin levels, and HFE polymorphism are potentially important predictors of ALT flare-up."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.org/dc/terms/identifier"doi:10.1007/s00535-007-2078-0"xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Hayashi K."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Kohara M."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Hasegawa S."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Kusumoto K."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Takahama Y."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Tsubouchi H."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Uto H."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Ido A."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Moriuchi A."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Stuver S.O."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Kurogi J."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/author"Oketani M."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/name"J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/pages"673-680"xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/title"Alanine aminotransferase flare-up in hepatitis C virus carriers with persistently normal alanine aminotransferase levels in a hyperendemic area of Japan."xsd:string
http://purl.uniprot.org/citations/17701131http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/17701131http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17701131
http://purl.uniprot.org/citations/17701131http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17701131
http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-17701131http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17701131
http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-17701131http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17701131
http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-17701131http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17701131
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