| http://purl.uniprot.org/citations/17704059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17704059 | http://www.w3.org/2000/01/rdf-schema#comment | "ADAM-9 belongs to a family of transmembrane, disintegrin-containing metalloproteinases involved in protein ectodomain shedding and cell-cell and cell-matrix interactions. The aim of this study was to analyze the expression of ADAM-9 in skin and to assess the role of this proteolytic/adhesive protein in skin physiology. In normal skin, ADAM-9 expression was detected in both the epidermis and dermis and in vitro in keratinocytes and fibroblasts. Here we report that ADAM-9 functions as a cell adhesion molecule via its disintegrin-cysteine-rich domain. Using solid phase binding assays and antibody inhibition experiments, we demonstrated that the recombinant disintegrin-cysteine-rich domain of ADAM-9 specifically interacts with the beta1 integrin subunit on keratinocytes. This was corroborated by co-immunoprecipitation. In addition, engagement of integrin receptors by the disintegrin-cysteine-rich domain resulted in ERK phosphorylation and increased MMP-9 synthesis. Treatment with the ERK inhibitor PD98059 inhibited MMP-9 induction. Furthermore, the presence of the soluble disintegrin-cysteine-rich domain did not interfere with cell migration on different substrates. However, keratinocytes adhering to the immobilized disintegrin-cysteine-rich domain showed increased motility, which was partially due to the induction of MMP-9 secretion. In summary, our results indicate that the ADAM-9 adhesive domain plays a role in regulating the motility of cells by interaction with beta1 integrins and modulates MMP synthesis."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701658200"xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Fox J.W."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Schild A."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Mauch C."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Nischt R."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Zigrino P."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Steiger J."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/author | "Loffek S."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/pages | "30785-30793"xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/title | "Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration."xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17704059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17704059 |
| http://purl.uniprot.org/citations/17704059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17704059 |
| http://purl.uniprot.org/uniprot/Q13443#attribution-40A14C9A850BDDBFA3E9B0652A54A416 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |
| http://purl.uniprot.org/uniprot/Q13443#attribution-7129D9C66696C820C470B991D9AD19BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |
| http://purl.uniprot.org/uniprot/Q13443#attribution-AC6EE2555D4C2D5E3C16A68B3C429A77 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |
| http://purl.uniprot.org/uniprot/P20930#attribution-10661D6847462FD758FAE17579524921 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |
| http://purl.uniprot.org/uniprot/P05556#attribution-7129D9C66696C820C470B991D9AD19BB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |
| http://purl.uniprot.org/uniprot/P14780#attribution-AC6EE2555D4C2D5E3C16A68B3C429A77 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17704059 |