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http://purl.uniprot.org/citations/17706335http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17706335http://www.w3.org/2000/01/rdf-schema#comment"

Background

Structural brain anomalies are present at early phases of psychosis. The objective was to examine the impact of Catechol-O-Methyltransferase (COMT) gene variations on brain morphology in first-episode non-affective psychosis. We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance imaging (MRI).

Methods

Fifty-two males and 23 females underwent COMT genotyping and MRI. Patients were categorized into three genetic subgroups: COMT(H/H), COMT(L/H) and COMT(L/L). MRI data were analyzed using BRAINS2. Global and lobar volumes of grey matter (GM) and cerebrospinal fluid (CSF) were compared among the three groups after controlling for total intracranial volume and age of illness onset.

Results

COMT(L) carriers showed a significant enlargement of the lateral ventricles (F = 7.13, p = 0.009), right lateral ventricle (F = 5.99, p = 0.017) and left lateral ventricle (F = 6.22, p = 0.015). No other significant differences in any of the brain structures were found among subgroups.

Conclusions

Our findings suggest that genetic variations of COMT can contribute to the enlargement of the lateral ventricles described in early phases of non-affective psychosis."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.org/dc/terms/identifier"doi:10.1016/j.pnpbp.2007.07.011"xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Jorge R."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Carrasco-Marin E."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Mata I."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Crespo-Facorro B."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Pelayo-Teran J.M."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Perez-Iglesias R."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Vazquez-Barquero J.L."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Gonzalez-Mandly A."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/author"Roiz-Santianez R."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/name"Prog Neuropsychopharmacol Biol Psychiatry"xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/pages"1514-1518"xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/title"Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis."xsd:string
http://purl.uniprot.org/citations/17706335http://purl.uniprot.org/core/volume"31"xsd:string
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