| http://purl.uniprot.org/citations/17706770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17706770 | http://www.w3.org/2000/01/rdf-schema#comment | "Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RARalpha (promyelocytic leukemia-retinoic acid receptor-alpha) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3), presently used in APL therapy. We have evaluated effects of ATRA and As2O3 treatment in PML-RARalpha-negative HL60 promyelocytic leukemia cells, harboring amplified c-myc. Characterization of expression and activity of c-Myc and its target genes hTERT (human telomerase reverse transcriptase) and CAD (carbamoyltransferase-dihydroorotase) revealed marked down-regulation in response to ATRA, but not As2O3. We suggest that blockage of terminal differentiation upon As2O3 treatment may be mediated through c-Myc."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2007.06.021"xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/author | "Henriksson M."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/author | "Jiang G."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/author | "Tang T."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/author | "Albihn A."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/pages | "297-307"xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/title | "Role of Myc in differentiation and apoptosis in HL60 cells after exposure to arsenic trioxide or all-trans retinoic acid."xsd:string |
| http://purl.uniprot.org/citations/17706770 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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