| http://purl.uniprot.org/citations/17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17707622 | http://www.w3.org/2000/01/rdf-schema#comment | "Growth and development of most parts of the vertebrate skeleton takes place by endochondral ossification, a process during which chondrocytes undergo distinct stages of differentiation resulting in a successive replacement of the cartilage anlagen by bone. In the context of an EST project we isolated a novel transcript from a human fetal growth plate cartilage cDNA library. The transcript which we called Ucma (unique cartilage matrix-associated protein) encodes a short protein of 138 amino acids. The protein sequence is evolutionary conserved throughout vertebrates and comprises a signal peptide, a coiled-coil domain, and a putative dibasic cleavage site for proprotein convertases. Using RNA in situ hybridization and immunohistochemistry with a polyclonal anti-Ucma antibody we found high expression of Ucma uniquely in distal (resting) chondrocytes in developing long bones of wildtype mice. This restricted expression could also be observed in Ihh(-/-), Ihh(-/-); Gli3(-/-), Gli3(-/-) mice, and in mice that overexpress Ihh under the control of the Col2a1 promoter indicating that expression of Ucma is regulated independent of hedgehog signaling. During insulin-induced differentiation of ATDC5 cells we found gradual increase of Ucma expression at day 21 with a maximum at day 24 and a decrease correlating with a simultaneous increase in the expression of cartilage link protein (Crtl1), a protein with maximum expression in column-forming proliferating chondrocytes. The present data strongly suggest an important function of Ucma in the early phase of chondrocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2007.07.004"xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Adam N."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Winterpacht A."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Vortkamp A."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Wuelling M."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Stock M."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Surmann-Schmitt C."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Tagariello A."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Luther J."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Didt-Koziel L."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/author | "Streiter M."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/pages | "3-11"xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/title | "Ucma--A novel secreted factor represents a highly specific marker for distal chondrocytes."xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17707622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17707622 |
| http://purl.uniprot.org/citations/17707622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17707622 |
| http://purl.uniprot.org/uniprot/#_A0A067XJP8-mappedCitation-17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17707622 |
| http://purl.uniprot.org/uniprot/#_A0A067XJX6-mappedCitation-17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17707622 |
| http://purl.uniprot.org/uniprot/#_A0A067XKV3-mappedCitation-17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17707622 |
| http://purl.uniprot.org/uniprot/#_D3YW77-mappedCitation-17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17707622 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VKQ8-mappedCitation-17707622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17707622 |