| http://purl.uniprot.org/citations/17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17715223 | http://www.w3.org/2000/01/rdf-schema#comment | "Human T-cell leukemia virus type 1 (HTLV-1) but not HTLV-2 is associated with adult T-cell leukemia, and the distinct pathogenicity of these two closely related viruses is thought to stem from the distinct biological functions of the respective transforming proteins, HTLV-1 Tax1 and HTLV-2 Tax2. In this study, we demonstrate that Tax1 but not Tax2 interacts with NF-kappaB2/p100 and activates it by inducing the cleavage of p100 into the active transcription factor p52. Using RNA interference methods, we further show that NF-kappaB2/p100 is required for the transformation induced by Tax1, as determined by the ability to convert a T-cell line (CTLL-2) from interleukin-2 (IL-2)-dependent to -independent growth. While Tax2 shows a reduced transforming activity relative to Tax1, Tax2 fused with a PDZ domain binding motif (PBM) present only in Tax1 shows transforming activity equivalent to that of Tax1 in CTLL-2 cells expressing an inducer of p52 processing. These results reveal that the activation of NF-kappaB2/p100 plays a crucial role in the Tax1-mediated transformation of T cells and that NF-kappaB2/p100 activation and PBM function are both responsible for the augmented transforming activity of Tax1 relative to Tax2, thus suggesting that these Tax1-specific functions play crucial roles in HTLV-1 leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00532-07"xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Fujii M."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Yoshida S."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Higuchi M."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Mahieux R."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Oie M."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Kondo R."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/author | "Tsubata C."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/pages | "11900-11907"xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/title | "Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line."xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/17715223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17715223 |
| http://purl.uniprot.org/citations/17715223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17715223 |
| http://purl.uniprot.org/uniprot/#_A0A1P8C958-mappedCitation-17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17715223 |
| http://purl.uniprot.org/uniprot/#_Q3UV15-mappedCitation-17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17715223 |
| http://purl.uniprot.org/uniprot/#_Q4U105-mappedCitation-17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17715223 |
| http://purl.uniprot.org/uniprot/#_Q4U106-mappedCitation-17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17715223 |
| http://purl.uniprot.org/uniprot/#_Q4U108-mappedCitation-17715223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17715223 |