| http://purl.uniprot.org/citations/17719010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17719010 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation. Its primary structure is identical to co-chaperone p23, a heat shock protein 90 (Hsp90)-binding protein. We have revealed that Hsp90 regulated both cPGES/p23 and its client protein kinase CK2. In this study, in order to examine the role of cPGES/p23 in vivo, we generated mice deficient in cPGES/p23 by a targeted disruption of exons 2 and 3, containing Tyr9, which is essential for catalytic activity. Heterozygotes are viable, fertile, and appear normal, despite a decrease in cPGES/p23 protein level. A generation of offsprings derived from intercrosses of cPGES/p23 homozygous mice revealed that 109, 247, and 10 pups were wild type, heterozygous, and homozygous, respectively; however, all homozygotes died at birth. The absence of viable null mutants, with heterozygotes and wild-type offspring obtained at a ratio of approximately 2:1, indicated that homozygosity for the cPGES/p23 null mutant leads to peri-natal lethality. Embryos homozygous for cPGES/p23-null had lower body weights than wild-type embryos, and abnormal morphology of skin and lungs. Moreover, the PGE(2) content in the lungs of cPGES/p23-null embryos was lower than that of the wild type. These results indicate that cPGES-derived PGES is involved in the normal development of mouse embryonic lung."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.07.180"xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Nakatani Y."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Kakuta S."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Sudo K."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Kudo I."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/author | "Hokonohara Y."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/pages | "387-392"xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/title | "Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal."xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://purl.uniprot.org/core/volume | "362"xsd:string |
| http://purl.uniprot.org/citations/17719010 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17719010 |
| http://purl.uniprot.org/citations/17719010 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17719010 |
| http://purl.uniprot.org/uniprot/#_D3Z7C6-mappedCitation-17719010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17719010 |
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| http://purl.uniprot.org/uniprot/#_Q9CRH1-mappedCitation-17719010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17719010 |
| http://purl.uniprot.org/uniprot/#_Q9R0Q7-mappedCitation-17719010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17719010 |
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| http://purl.uniprot.org/uniprot/Q3TJG6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17719010 |
| http://purl.uniprot.org/uniprot/Q9CRH1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17719010 |
| http://purl.uniprot.org/uniprot/D3Z7C6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17719010 |