| http://purl.uniprot.org/citations/17719550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17719550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17719550 | http://www.w3.org/2000/01/rdf-schema#comment | "The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit-like hopping gait, impaired corticospinal axon guidance, and abnormal spinal central pattern generators. Using positional cloning, transgene rescue, and gene targeting, we demonstrated that loss of alpha-chimerin leads to mfy phenotypes similar to those of EphA4(-/-) and ephrinB3(-/-) mice. alpha-chimerin interacts with EphA4 and, in response to ephrinB3/EphA4 signaling, inactivates Rac, which is a positive regulator of process outgrowth. Moreover, downregulation of alpha-chimerin suppresses ephrinB3-induced growth cone collapse in cultured neurons. Our findings indicate that ephrinB3/EphA4 signaling prevents growth cone extension in motor circuit formation via alpha-chimerin-induced inactivation of Rac. They also highlight the role of a Rho family GTPase-activating protein as a key mediator of ephrin/Eph signaling."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.07.022"xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.07.022"xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Ishikawa Y."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Negishi M."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Negishi M."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Takahashi R."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Takahashi R."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Katoh H."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Katoh H."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Itohara S."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Itohara S."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Iwama M."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Iwama M."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Ando R."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Ando R."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Iwasato T."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Iwasato T."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Nishimaru H."xsd:string |
| http://purl.uniprot.org/citations/17719550 | http://purl.uniprot.org/core/author | "Nishimaru H."xsd:string |