| http://purl.uniprot.org/citations/17720976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17720976 | http://www.w3.org/2000/01/rdf-schema#comment | "Cripto-1 (CR-1) is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that has been shown to play an important role in embryogenesis and cellular transformation. CR-1 is reported to function as a membrane-bound co-receptor and as a soluble ligand. Although a number of studies implicate the role of CR-1 as a soluble ligand in tumor progression, it is unclear how transition from the membrane-bound to the soluble form is physiologically regulated and whether differences in biological activity exist between these forms. Here, we demonstrate that CR-1 protein is secreted from tumor cells into the conditioned medium after treatment with serum, epidermal growth factor, or lysophosphatidic acid, and this soluble form of CR-1 exhibits the ability to promote endothelial cell migration as a paracrine chemoattractant. On the other hand, membrane-bound CR-1 can stimulate endothelial cell sprouting through direct cell-cell interaction. Shedding of CR-1 occurs at the GPI-anchorage site by the activity of GPI-phospholipase D (GPI-PLD), because CR-1 shedding was suppressed by siRNA knockdown of GPI-PLD and enhanced by overexpression of GPI-PLD. These findings describe a novel molecular mechanism of CR-1 shedding, which may contribute to endothelial cell migration and possibly tumor angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m702713200"xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Hamada S."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Watanabe K."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Wen D."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Gonzales M."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Bianco C."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Salomon D.S."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Sanicola M."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Seno M."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Miatkowski K."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Mo W."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Mancino M."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Strizzi L."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/author | "Bailly V."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/pages | "31643-31655"xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/title | "Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration."xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17720976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17720976 |
| http://purl.uniprot.org/citations/17720976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17720976 |
| http://purl.uniprot.org/uniprot/O70362#attribution-89AAE36FA7C36745DC1DB38A68B40A4A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17720976 |
| http://purl.uniprot.org/uniprot/P80108#attribution-3BC1A599B2F9ECB12CEEAA9E010F483A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17720976 |