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http://purl.uniprot.org/citations/17721195http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17721195http://www.w3.org/2000/01/rdf-schema#comment"Low-grade fibromyxoid sarcomas (LGFMS) bear either the t(7,16) (q32-34;p11) or t(11,16) (p11;p11) translocations, resulting in FUS-CREB3L2 or FUS-CREB3L1 fusions, respectively. Heretofore, fusion transcripts were mainly detected in frozen tissues, using reverse transcription-polymerase chain reaction. In this study, we aimed to develop a reliable method to detect these in paraffin-embedded tissues, and to examine the clinicopathologic characteristics of a series of translocation-positive LGFMS. Sixty-three neoplasms with typical morphologic features of LGFMS and 66 non-LGFMS tumors selected for their resemblance to LGFMS (LGFMS-like tumors) were examined. RNA of sufficient quality could be extracted from 111/129 (86%) cases (59 LGFMS, 52 non-LGFMS). Of all, 48/59 (sensitivity, 81%) LGFMS contained detectable transcripts (45 FUS-CREB3L2, 3 FUS-CREB3L1). Most relevant clinicopathologic features of fusion-positive LGFMS included predominance in lower extremities (22/48; thigh: 13/48), deep situation (46/48), and occasional presence of unusual histologic features, for example, hypercellular areas (16/48), foci of epithelioid cells (13/48), and giant rosettes (6/48). Most tumors expressed EMA (41/45), at least focally, CD99 (38/41) and bcl-2 (36/41) while being essentially negative for CD34 (2/45), mdm2 (1/41), smooth muscle actin (1/45), S100 protein (0/46), desmin (0/44), h-caldesmon (0/42), keratins (0/44), and CD117 (0/40). Eleven presumed LGFMS were fusion negative. Of all, 7/52 non-LGMFS neoplasms contained FUS-CREB3L2 transcripts, of which 4 had been diagnosed as sclerosing epithelioid fibrosarcoma. In conclusion, FUS-CREB3L1/L2 fusion transcripts can be detected in paraffin-embedded LGFMS in a sensitive manner, using reverse transcription-polymerase chain reaction. Most fusion-positive LGFMS are EMA-positive and CD34/S100/smooth muscle actin negative. The presence of epithelioid cells and fusion transcripts in both LGFMS and a subset of sclerosing epithelioid fibrosarcoma suggest that these neoplasms might be related."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.org/dc/terms/identifier"doi:10.1097/pas.0b013e3180321959"xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Gallagher G."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Collin F."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Pedeutour F."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Keslair F."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Benhattar J."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Marques B."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Leroux A."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Terrier P."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Guillou L."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Coindre J.M."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Terrier-Lacombe M.J."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Aubain Somerhausen N.d.e. S."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Gengler C."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/author"Ranchere-Vince D."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/name"Am J Surg Pathol"xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/pages"1387-1402"xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/title"Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group."xsd:string
http://purl.uniprot.org/citations/17721195http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/17721195http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17721195
http://purl.uniprot.org/citations/17721195http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17721195
http://purl.uniprot.org/uniprot/#_A2RRN1-mappedCitation-17721195http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17721195
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