| http://purl.uniprot.org/citations/17723228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17723228 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-13 has been reported as one of the major down-regulators of iNOS expression in various tissues and cells. The molecular mechanism of iNOS suppression by IL-13 remains unclear, especially at the transcriptional stage. In this study, we found that IL-13 inhibited the expression of iNOS mRNA, protein, and NO product in a concentration-dependent manner for cytokine-stimulated rat hepatocytes. The most effective dose for IL-13 inhibitory effect is approximately 5 ng/ml. IL-13 also decreased the rat iNOS transcriptional activity by promoter analysis, but had no effect on iNOS mRNA stability. By using TranSignal Protein/DNA Combo Array, we identified cytokine-stimulated IRF-1/ISRE binding that was decreased by the addition of IL-13. Gel shift assay confirmed that IL-13 reduced the IRF-1/ISRE binding at nucleotides -913 to -923 of the rat iNOS promoter. Western blot revealed that IL-13 diminished the relative amount of IRF-1 protein translocated to the nucleus. Our data demonstrate that IL-13 down-regulates the cytokine-induced iNOS transcription by decreasing iNOS specific IRF-1/ISRE binding activity."xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.07.203"xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/author | "Shao L."xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/author | "Geller D.A."xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/pages | "582-586"xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/title | "Transcriptional suppression of cytokine-induced iNOS gene expression by IL-13 through IRF-1/ISRE signaling."xsd:string |
| http://purl.uniprot.org/citations/17723228 | http://purl.uniprot.org/core/volume | "362"xsd:string |
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