| http://purl.uniprot.org/citations/17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17726164 | http://www.w3.org/2000/01/rdf-schema#comment | "Hematopoietic cell transplantation (HCT) from an HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele-matched unrelated donor is a well-recognized life-saving treatment modality for patients with hematologic disorders. The morbidity and mortality from clinically significant acute graft-versus-host disease (aGVHD) remains a limitation. The extent to which transplantation outcome may be improved with donor matching for HLA-DP is not well defined. The risks of aGVHD, relapse, and mortality associated with HLA-DPB1 allele mismatching were determined in 5929 patients who received a myeloablative HCT from an HLA-A-, HLA-B-, HLA-C-, HLA-DRB1-, and HLA-DQB1-matched or -mismatched donor. There was a statistically significantly higher risk of both grades 2 to 4 aGVHD (odds ratio [OR] = 1.33; P < .001) and grades 3 to 4 aGVHD (OR = 1.26; P < .001) after HCT from an HLA-DPB1-mismatched donor compared with a matched donor. The increased risk of aGVHD was accompanied by a statistically significantly decrease in disease relapse (hazard ratio [HR] = 0.82; P = .01). HLA-DPB1 functions as a classical transplantation antigen. The increased risk of GVHD associated with HLA-DPB1 mismatching is accompanied by a lower risk of relapse. Knowledge of the DPB1 matching status prior to transplantation will aid in more precise risk stratification for the individual patient."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-06-095265"xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Madrigal J.A."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Begovich A.B."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Marsh S.G."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Petersdorf E.W."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Gratwohl A."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Malkki M."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Shaw B.E."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Ringden O."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Gooley T.A."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/author | "Horowitz M.M."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/pages | "4560-4566"xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/title | "The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/17726164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17726164 |
| http://purl.uniprot.org/citations/17726164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17726164 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17726164 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17726164 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17726164 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17726164 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-17726164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17726164 |