| http://purl.uniprot.org/citations/17726369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17726369 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuropilin-1 (Np-1) is a coreceptor for vascular endothelial growth factor-A (VEGF-A), and both are expressed at high levels in pancreatic ductal adenocarcinomas (PDACs). While VEGF-A has been implicated in tumor angiogenesis, the role of Np-1 in PDAC is less clearly defined. Accordingly, PANC-1 pancreatic cancer cells, which express relatively high levels of Np-1, were transfected with the Np-1 antisense cDNA. By comparison with sham transfected cells, Np-1 antisense expressing clones (Np-1AS) exhibited decreased anchorage independent growth, adhesion and invasiveness, and prolonged doubling times. Np-1AS were also more sensitive to the pro-apoptotic actions of ActD, as evidenced by PARP cleavage, caspase 9 activation and annexin V staining. ActD decreased Bcl-xL and STAT5 levels in the antisense expressing cells, but not in sham-transfected cells, and did not alter STAT3, Bcl-2, phospho-AKT, AKT, Bad, Bax or Bak levels. Immunoprecipitation followed by immunoblotting revealed that Np-1 associated with integrin beta1 and integrin beta1 blockade attenuated adhesion. However, Np-AS expressing clones exhibited enhanced tyrosine phosphorylated focal adhesion kinase. Thus, Np-1 confers a growth and survival advantage to PANC-1 cells, and interacts with integrin beta1 to coordinate signaling events that promote cell adherence and invasiveness."xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.org/dc/terms/identifier | "doi:10.4161/cbt.6.8.4363"xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/author | "Matsushita A."xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/author | "Fukasawa M."xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/author | "Korc M."xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/name | "Cancer Biol Ther"xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/pages | "1173-1180"xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/title | "Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasion."xsd:string |
| http://purl.uniprot.org/citations/17726369 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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